From: DeskNow Knowledge Base
http://www.desknow.com/kb/

The DeskNow service does not start in Windows
http://www.desknow.com/kb/idx/5/030/article/

First of all, make sure that DeskNow can start in Console (see the menu folder Start/Program Files/Desknow/Advanced).

If it doesn't start in console, then check the error messages that are shown in the console window, or in the log.Init files, or in C:\Program Files\DeskNow\logs for more clues. Typically the main cause is that there is another Web server or Mail using the same ports that DeskNow is trying to use.

If DeskNow can start fine in console, but not as service: