From: DeskNow Knowledge Base
http://www.desknow.com/kb/

Can DeskNow run on my system?
http://www.desknow.com/kb/idx/12/036/article/

DeskNow server can run on most systems, inlcuding Windows (Windows 98, XP, Windows 2000, Windows Server 2003, and NT 4), Linux, BSD, and Mac OS X.

Basically the main requirements are:

128 Mb RAM (256 recommended)

availability of Java 1.4.1 or later (this is included in the Windows version)

DesKNow can also coexist with other popular Web servers like IIS (see http://www.desknow.com/kb/idx/12/034/article/ ) and Apache (see http://www.desknow.com/kb/idx/12/035/article/ ).