From: DeskNow Knowledge Base
http://www.desknow.com/kb/

How do I use DeskNow as web server for other virtual domains?
http://www.desknow.com/kb/idx/5/067/article/

DeskNow uses Apache Tomcat as its web server core technology. Please note that Apache Tomcat is not the standard Apache httpd daemon, but is a separate software, which is a web server and much more.

To configure a virtual domain in Tomcat, simply edit the file server.xml (in C:Program FilesDeskNowconf , or /var/desknow/conf on Linux/Unix)

and below the existing <Host> section add the following lines:

      <Host name="www.otherdomain.com" appBase="webapps">
       <Context docBase="C:\www\otherdomain\" path=""/>
      </Host>


(replace www.otherdomain.com with the virtual domain name, and C:\www\otherdomain\ with the folder where the HTML files are located - make sure to leave the \ character at the end).

Then copy the folder C:\Program Files\DeskNow\webapps\ROOT\WEB-INF to C:\www\otherdomain\ .

Then restart DeskNow.