From: DeskNow Knowledge Base

450 Recipient address rejected: Try again later

This is a common response message coming from mail servers that implement an antispam measure called greylisting.

The server rejects a connection the first time. A spammer will not bother retrying later, but honest servers will. The second connection will be accepted. For more details, see

As stated in the message, DeskNow will retry later, and the email delivery will typically succeed (if it does not, DeskNow will try again a few times, and if even the last attempt fails, DeskNow will send a second bounce message stating that the error is permanent).

If you do not want to receive these warnings, you can disable them by unchecking the option Administration/Mail/SMTP Outgoing/Delivery attempts/Send delivery error notification for first attempt.